Skip to product information
1 of 7

Radiance Defense Boost

Radiance Defense Boost

4.6
Rated 4.6 out of 5 stars
4.6 Stars (7 Reviews)

Dull skin in perimenopause isn't aging. It's hormonal.

Regular price $59.00
Sale price $59.00 Regular price
Save Sold out
  • Dull skin, puffiness, and that flat feeling that won't lift - this is where that starts.

  • Supports healthy estrogen metabolism so excess hormones move through your body the way they're supposed to, not recirculate.*

  • Activates your body's own repair system using sulforaphane from broccoli seed extract - the one that slows down after 40.

  • Formulated by Dr. Anna Cabeca, triple-board-certified OB/GYN, specifically for women in perimenopause and beyond.

Choose an Option:

Check this box to have your order shipped at the front of the line for $6.99! View details

Ship Me First

Your order will be packed and shipped before others — a little love, a little speed, and a lot of Girlfriend Doctor care. Not available on subscription renewals.

cGMP certification

Manufactured in a facility that follows current Good Manufacturing Practices (cGMP)

View full details
Radiance Defense Boost

Radiance Defense Boost

  • Non-GMO

  • Gluten Free

  • Vegan

What changes when your cells are actually protected

What You'll Actually Notice

  • Your body has a repair system that slows down in perimenopause. This wakes it back up.
    Your body was built to protect itself every day. By your mid-40s, the internal process that handles that gets sluggish, and you feel it - in your skin, your energy, and the way your body responds to stress. Radiance Defense Boost contains glucoraphanin from broccoli seed extract, a compound that activates your body's own cellular defense and detox pathways from the inside, not just for a few hours but on an ongoing basis.*
  • Supports healthy estrogen metabolism so your hormones move through, not pile up.*
    When estrogen isn't processed efficiently, it recirculates. That recirculating estrogen shows up as bloating, breast tenderness, mood swings, and skin that looks congested and tired no matter what you put on it. This formula supports the detox pathways your body uses to clear excess estrogen, so your hormones move through your body the way they're supposed to.*
  • Skin that looks clearer because something is actually different inside.
    Dull, tired-looking skin in midlife is not just aging. It is your body's daily burden showing up on your face. By supporting the internal cleanup your cells do every day, Radiance Defense Boost contributes to skin that looks less inflamed and more even, because what changed is underneath - not on the surface.
  • Daily support for the cellular wear that comes from living - stress, toxins, hormonal shifts, and everything in between.*
    Stress. Environmental toxins. Food. Hormonal fluctuations. They all create cellular wear your body has to manage, every single day. Radiance Defense Boost delivers activated folate (5-MTHF at 1,700 mcg DFE, 425% DV) and Vitamin C to support DNA repair, collagen production, and immune resilience. The quiet maintenance your body is doing whether you feel it or not.*

Want to understand how skin and hormones connect? Dr. Anna walks through it on the podcast - Clean Skin From Within with Dr. Trevor Cates - and in the blog Essential Nutrients for Glowing Skin.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

What's Inside And Why It Matters

Each capsule contains:

  • Vitamin C (as ascorbic acid): 100 mg | 111% DV
  • Folate (as (6S)-5-methyltetrahydrofolic acid): 1,700 mcg DFE | 425% DV
  • Glucoraphanin (from broccoli seed extract, Brassica oleracea italica): 30 mg
  • Horseradish (Armoracia rusticana, high in myrosinase): 18.75 mg
  • Other Ingredients: HPMC (vegetarian capsule), Microcrystalline cellulose, Ascorbyl palmitate.

Gluten-free. Non-GMO. Vegan. 30 capsules per bottle. Take 1 capsule daily, with or without food.

----

Why these four ingredients, and not a longer list:

Most antioxidant formulas stack dozens of ingredients. I kept this formula tight on purpose. Every ingredient in Radiance Defense Boost has a specific job, and they work as a system. The glucoraphanin and horseradish work together - one supplies the raw material, the other supplies the enzyme that activates it. Folate at 425% DV in its active form (5-MTHF) supports the detox and DNA repair pathways that become less efficient in perimenopause. Vitamin C supports collagen and immune resilience. Nothing in here is decorative.

The Science, In Plain English

Most antioxidant supplements give you a single dose of protection that your body burns through in a few hours. Radiance Defense Boost is built on a different idea.

The key ingredient is glucoraphanin from broccoli seed extract. On its own, glucoraphanin does nothing. It is a precursor. It needs to be converted.

That conversion happens because of the second ingredient: horseradish. Horseradish is naturally rich in the enzyme myrosinase, and myrosinase is what converts glucoraphanin into sulforaphane right inside your body. This is the step most broccoli supplements miss - they deliver glucoraphanin without the enzyme, so most of it passes through unused.

Once sulforaphane is produced, it activates Nrf2, your body's master protective switch. Nrf2 triggers your own long-lasting antioxidant enzymes - not a borrowed dose from a capsule, but your body's own production, running for hours.

The folate in this formula is 5-MTHF, the activated form. Standard folic acid requires a conversion step that many women over 40 do less efficiently. By using 5-MTHF at 1,700 mcg DFE (425% DV), this formula bypasses that step entirely and delivers folate your body can use immediately for DNA repair and detox support.

Vitamin C at 111% DV provides the foundational antioxidant support that collagen synthesis and immune resilience depend on.

One capsule. Four ingredients. A system that runs on your biology, not despite it.

I talked about why broccoli alone isn't enough and how the Nrf2 pathway works in everyday life on this episode of the podcast: Food as Medicine for Healthy and Radiant Skin.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FAQ

How is this different from just eating broccoli?

Broccoli contains glucoraphanin, but cooking destroys the myrosinase enzyme needed to activate it. Radiance Defense Boost delivers both together in a stable, precise dose — so you get the sulforaphane activation your body needs.

Can I take this with Keto-Green Detox?

Yes. They work differently and complement each other well. Keto-Green Detox supports your liver’s ability to clear toxins and excess hormones. Radiance Defense Boost activates your body’s ongoing cellular defense system. Together they address both clearing and protecting.

Is this safe for women in perimenopause or menopause?

Yes. The formula was designed with perimenopausal and menopausal women in mind, supporting the hormonal detox and cellular protection pathways most relevant during this transition. As always, consult your healthcare practitioner if you are on medication.

When should I take it?

Take 1 capsule daily by mouth. Can be taken with or without food.

What does Radiance Defense Boost actually do for women in perimenopause?

Radiance Defense Boost supports the body’s natural cellular repair and detox processes — the systems that start slowing down as hormones shift in perimenopause. It contains glucoraphanin from broccoli sprout extract, which the body converts into a compound that helps activate its own internal defense pathways. Women often take it to support clearer skin, healthier hormone metabolism, and more consistent energy during the hormonal changes of their 40s and 50s.

Why is my skin getting dull and puffy in my 40s — and can a supplement help?

In perimenopause, declining estrogen affects skin cell turnover, collagen production, and how efficiently the body clears daily cellular waste. The result is skin that looks more tired, congested, or puffy — even when nothing in your routine has changed. A supplement formulated to support cellular detox and healthy hormone metabolism, like Radiance Defense Boost, may help address some of the internal drivers behind these changes rather than just treating the surface.

What is glucoraphanin and why is it in a women’s hormone supplement?

Glucoraphanin is a naturally occurring compound found in broccoli sprouts — one of the most concentrated dietary sources known. On its own it’s relatively inactive, but once inside the body it converts into a bioactive compound that supports the body’s own antioxidant and detoxification systems. It’s included in Radiance Defense Boost because those systems — cellular repair, detox, inflammatory balance — are directly connected to how women feel during hormonal transitions in perimenopause and menopause.

How long does it take to see results from Radiance Defense Boost?

Most women taking Radiance Defense Boost consistently report noticing changes over 4 to 8 weeks — not days. This is because the formula works by supporting the body’s natural cellular and detox processes rather than delivering an immediate stimulant effect. Early changes women often notice first include skin that looks less puffy or inflamed, and a subtle shift in energy or clarity. More significant changes in skin tone, hormonal balance, and overall resilience tend to build over 60 to 90 days of daily use.

Is Radiance Defense Boost safe to take with hormone therapy or other supplements?

Radiance Defense Boost is formulated with naturally occurring compounds from broccoli sprout extract, activated folate (5-MTHF), and Vitamin C — ingredients that are generally well tolerated. It is designed to be complementary to broader wellness routines, including hormone support protocols. That said, if you are currently on hormone therapy, prescription medications, or have a diagnosed condition, it’s always best to review any new supplement with your healthcare provider before starting.

What makes Radiance Defense Boost different from other women’s supplements for hormone support?

Most hormone support supplements for women focus on adding something — botanicals, adaptogens, phytoestrogens. Radiance Defense Boost works differently. It’s built around activating what your body already knows how to do — specifically the cellular repair and detox pathways that become less efficient during perimenopause and menopause. It was formulated by Dr. Anna Cabeca, a triple board-certified OB/GYN with over 20 years of clinical experience treating women in hormonal transition, and it includes an enzyme (myrosinase) to ensure the key compound actually converts properly inside the body — something most broccoli sprout supplements skip.

Can post-menopausal women take Radiance Defense Boost — or is it only for perimenopause?

Radiance Defense Boost is designed for women across the full hormonal transition — perimenopause, menopause, and post-menopause. Post-menopausal women often face increased cellular stress and slower natural detox processes as estrogen drops permanently, which makes cellular support even more relevant — not less. Many women over 55 take Radiance Defense Boost specifically for skin health, immune resilience, and long-term vitality support.

  • Broccoli Sprout Extract

    Glucoraphanin, a precursor compound from broccoli seed that converts into sulforaphane inside the body—activating your body’s Nrf2 pathway, the master switch for cellular protection and antioxidant production.

  • Horseradish

    Provides the myrosinase enzyme that activates glucoraphanin into sulforaphane. Without myrosinase, most glucoraphanin passes through unused. This pairing ensures full activation.

  • Folate

    The activated, bioavailable form of folate, 5-MTHF, bypasses conversion issues common with folic acid. Supports DNA repair, methylation, and phase I/II detoxification at 1,700 mcg DFE (425% DV).

  • Vitamin C

    Ascorbic acid, a foundational antioxidant that neutralizes free radicals, supports immune function, and is essential for collagen synthesis, contributing to skin firmness and radiance.​​​​​​​​​​​​​​​​

  • At a Glance

    • 30 vegetarian capsules
    • 1 capsule per day
    • Gluten-free | Non-GMO | Vegan
    • Doctor-formulated
  • Benefits

    • Cellular defense activated from within
    • Skin radiance + oxidative protection
    • Healthy estrogen metabolism support*
    • DNA repair and methylation support
    • Immune resilience*

*Product reviews solely reflect the views and opinions expressed by individual contributors and not those of Golden Isles Medical, Inc dba The Girlfriend Doctor. Golden Isles Medical, Inc dba The Girlfriend Doctor does not verify or endorse any claims made in these reviews. Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

4.6
Rated 4.6 out of 5 stars
Based on 7 reviews
Total 5 star reviews: 5 Total 4 star reviews: 1 Total 3 star reviews: 1 Total 2 star reviews: 0 Total 1 star reviews: 0
86%would recommend this product
7 reviews
  • FD
    Florence D.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    21 seconds ago
    Radiance

    Great product, personally recommended by Dr Anna on one of the calls she gave to the community, about better metabolising estradiol. Re-ordering now!

  • AR
    Anne R.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    6 days ago
    Sudden energy!

    Ive always been a fan of vegetables especially Broccoli! It has so many health benefits. Unfortunately, I don't always eat the recommended amount on a daily basis. Well, I was delighted to see try this new supplement from DR Cabecca! First week, I noticed such an increase in energy, my skin was glowing, and nails were growing strong and long. And I especially love the detoxification benefits it provides. This product is a win win !!! Thank you Dr Cabecca

  • C
    Cheryl
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    More energy at 62 years young!

    I noticed more energy and less brain fog after 4 weeks of use. I love it and will be reordering!

  • SK
    Shirley K.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    4 weeks ago
    Review will be the same as the last for Radiance Defense.

    Great, clean product! Thx

  • LT
    Lori T.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    My Daily Wellness Routine

    I originally started taking it to support healthy aging and overall cellular wellness, but I have noticed so many additional benefits.

    Within a few weeks, I felt less sluggish, less bloated, and more balanced overall. My skin appears brighter and healthier, and I love knowing that I am supporting my body from the inside out during this stage of life. The ingredients are thoughtfully selected, and I appreciate Dr. Anna’s focus on women’s health, especially during perimenopause and menopause.

    Another thing I love is that it is easy to incorporate into my daily routine and does not leave me feeling jittery or uncomfortable like some wellness supplements can. The quality is excellent, and I feel confident knowing it comes from a brand I trust.

    If you are looking for additional support for healthy aging, cellular wellness, and overall vitality, I highly recommend giving Radiance Defense Boost a try. It has been a wonderful addition to my wellness journey, and I will definitely continue using it.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.